Cross-over Trials in Clinical Research

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Title: Cross-over Trials in Clinical Research
ISBN: 0471934933
Author: Stephen Senn
Publicate Date: 1993-03-16
Publish: 1993-03-16
List Price: $120.00
Average Customer Rating: 5.0
Format: Hardcover

Amazon Lowest New Price: $147.93
Amazon Lowest Used Price: $38.00




Customer Review:

1: great book with cross-over trials vert useful when testing equivalence Stephen Senn is a great writer and an excellent applied statistician. He has written a number of excellent books related to the conduct of clinical trials. This is the second edition of the book and it is even an improvement of the first which was also excellent and often consulted! A nice thing about Senn with all of his books is that he does not shy away from controversy. He also is very careful in his presentation and he avoids common mistakes and points out the mistakes of others. I recently got a deeper appreciation for this book when I had to design a crossover equivalence trial while I was employed at Auxilium about 10 months ago. Senn does a very thorough job of explaining the AB/BA design which although simpler than many of the others is commonly used. Most of the important concepts in cross-over designs such as the washout period and the within subject variability can be address in this simplest of cross-over designs. This book is an excellent reference for any statistician that gets involved in cross-over trials. It is clear concise and strong on concepts but also detailed enough to make the correct mathematics clear. Cross-over trials have the advantage of potentially reducing variability since each subject acts as his own control. But to avoid confounding, a washout period with the subject off treatment is required so that the effect of the earlier treatment is not influencing the results for the next treatment. Sometimes this constraint can make recruiting difficult and there can be other logistic issues that can make it infeasible.

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